Yes, this sketch is clearly in reference to this comic and its commentary. And Zelda fairies. And Scarface. And David Boreanaz.

How does it involve David Boreanaz? All things involve David Boreanaz. When the universe was born in the big bang, he was actually right there in the middle of it, sent flying through the universe, dazed, confused, and dreaming of one day portraying a vampire with a soul and a really cool FBI guy on television. He eventually slingshotted around the densest star of the furthest galaxy and was flung back to Earth where he crash landed on Joss Whedon's house, and thus his legend as we know it began.

...What? I had to pad this commentary out somehow. And have I mentioned that I met Joss Whedon and shook his hand once? Yeah, I met Joss Whedon and shook his hand once. I just thought I should mention that in case you weren't aware that I met Joss Whedon and shook his hand once.