Grace is good at video games, yo.
This is clearly in reference to Super Smash Bros, which I suppose makes this commentary somewhat timely. Transgender Princess is clearly in reference to Zelda turning into Sheik (I still say Sheik is anatomically male), and the electric two-tailed squirrel is clearly in reference to Pikachu. I believe the two tails is in reference to a Jacob's Ladder and NOT Tails from Sonic The Hedgehog, though I suppose it could have been both. It was definitely in reference to a Jacob's Ladder, however.
Back when I created this comic, I had only ever heard of "transgender" in reference to transformation. Nonetheless, I think it holds up. Either the princess remains a constant gender (i.e. identifies as a man or woman regardless of whether anatomically male or female), or her gender identity changes with the transformation. Either way, it seems appropriate, though some may prefer "Trans Princess".
Commentary added December 22, 2014